Accounting for interface behaviour in multi-stage aqueous two-phase extraction
نویسندگان
چکیده
• Increased resolution in a continuous, cheaper protein purification technique. Reduced experimental workload and need for extensive screening. Modelling evaluated against multi-stage aqueous two-phase extraction. accuracy gained by consideration of interfacial behaviour. Aqueous extraction (ATPE) is an alternative, continuous For ATPE to be used industry, it must compete with current batch procedures, which can achieved using operation. To design processes appropriate process models developed. In this study, experimentally determined single-stage equilibrium data was generate model describe the behaviour counter-current ATPE. Two distribution systems are considered: liquid–liquid (LL) liquid-interface-liquid (LIL) distribution. The LIL considers material precipitates at interface system. These were then both compared three-stage case study described system better than LL model, reducing error from 40% 11%. With significant increase accuracy, represents important tool processes.
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ژورنال
عنوان ژورنال: Chemical Engineering Science
سال: 2021
ISSN: ['1873-4405', '0009-2509']
DOI: https://doi.org/10.1016/j.ces.2020.116172